February 6, 2001
Mycophenolic acid (MPA) inhibits inosine monophosphate dehydrogenase and is active against HIV-1 in vitro. Reverse transcriptase inhibitors, such as dideoxyinosine and tenofovir, which are ultimately metabolized to adenosine analogs, are processed through the inosine pathways. MPA administration represents a possible way of augmenting the activity of these agents.
In this laboratory study, MPA was used at a range of doses (0-500 nM) which represent achievable serum concentrations. In combination with these NRTIs, both wild-type and resistant clones were inhibited in a dose-proportional manner. The use of MPA together with ddI and ABC demonstrated synergy. Neither the NRTIs nor MPA had an adverse effect on cell proliferation.
These data suggest that MPA may be a useful adjunct to therapy with ddI, abacavir and tenofovir at doses of MPA that do not induce immunosuppression, and is worthy of further clinical testing.
|Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.|