Advertisement
Advertisement

Read Now: News and Research From IDWeek 2014

Abstracts: Incidence of Cardiac Abnormalities in Children With Human Immunodeficiency Virus Infection

October 2002


This article is part of The Body PRO's archive. Because it contains information that may no longer be accurate, this article should only be considered a historical document.

Objective: To describe the five-year cumulative incidence of cardiac dysfunction in human immunodeficiency virus (HIV)-infected children.

Study Design: We used a prospective cohort design, enrolling children at 10 hospitals. Group I included 205 vertically HIV-infected children enrolled at a median age of 1.9 years. Group II consisted of 600 HIV-exposed children enrolled prenatally or as neonates, of whom 93 were ultimately HIV-infected. The main outcome measures were echocardiographic indexes of left ventricular dysfunction.

Results: In Group I, the five-year cumulative incidence of left ventricular fractional shortening <25 percent was 28 percent. The five-year incidence of left ventricular end-diastolic dilatation was 21.7 percent, and heart failure and/or the use of cardiac medications 28.8 percent. The mortality rate one year after the diagnosis of heart failure was 52.5 percent [95 percent CI, 30.5-74.5]. Within Group II, the five-year cumulative incidence of decreased fractional shortening was 10.7 percent in the HIV-infected compared with 3.1 percent in the HIV-uninfected children (p= .01). Left ventricular dilation, heart failure, and/or the use of cardiac medications were more common in infected compared with uninfected children.

Conclusions: During five years of follow-up, cardiac dysfunction occurred in 18 percent to 39 percent of HIV-infected children and was associated with an increased risk of death. [T.J. Starc et al.; J Pediatr; 2002 Sep;141(3):327-34.]

Advertisement

Back to the October 2002 issue of IAPAC Monthly.




This article was provided by International Association of Physicians in AIDS Care. It is a part of the publication IAPAC Monthly.
 

Advertisement