September 20, 2017
A useful poster reported that very early initiation of ART, followed by several years of viral suppression, can have a relatively common outcome of testing HIV negative using rapid HIV tests.
The negative results from the waning HIV antibody responses are rarely reported when ART is started later in infection. Importantly, the results only highlight a limitation for the test sensitivity and not that HIV has been cleared.
This study was presented as a poster by Karl Stefic from an analysis of 44 participants in the French ANRS primary HIV infection (PHI) PRIMO cohort who started ART dueing PHI and who had undetectable viral load for at least the following three years.
Participants were mostly male (82%), median age was 40 years. At diagnosis, median CD4 cell count was 372 cells/mm3 and plasma viral load and cell-associated HIV-DNA were 5.3 and 3.6 log10 copies/million PBMCs, respectively.
ART was started a median of 43 days (range 20-115) after estimated date of infection. This corresponded to Fiebig stage II (5%), III (2%), IV (36%), V (21%) or VI (36%).
After a median of 84 months (range 36-204) on ART, HIV-specific serological responses were non-reactive for 30% of self-tests, 9% for INSTI and 7% for VIKIA. All participants remained positive with 4th generation ELISA (median index=48; range: 1.9 to 491) but 7/44 had an index value < 10.0.
Cell associated HIV-DNA at time of self-test was not associated with non-reactivity. Of note HIV-DNA remained detectable for 9/13 patients (69%) with negative self-test. Under ART, western blot were indeterminate for 4/13 patients with non-reactive self-tests (31%) compared to 2/31 patients with reactive self-tests (6%).
The poster also noted that awareness of this possibility might be important for people using HIV self-testing in the future.
Karl Stefic K et al. Non-reactive HIV-1 self-tests after sustained viral suppression following early antiretroviral therapy. IAS 2017, 23-26 July 2017, Paris. Poster abstract MOPOB0253.
http://programme.ias2017.org/Abstract/Abstract/1246 (abstract and poster)
[Note from TheBody.com: This article was originally published by HIV i-Base on Sept. 20, 2017. We have cross-posted it with their permission.]
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