July 24, 2017
Last month, the Cochrane Review published a controversial paper on HCV therapy that left many ID doctors and hepatologists perplexed.
After reviewing 138 randomized clinical trials using directly acting, non-interferon based therapies, they came to the following conclusions:
Anyone -- clinician, researcher, or patient -- who has experienced the miraculous advances in HCV therapy that started in 2014 could easily be scratching their heads at these conclusions.
The FDA might be surprised as well, since they have allowed SVR as an appropriate "surrogate" marker of the effectiveness of HCV therapy for some time.
Fortunately, we now have a focused, persuasive response by the IDSA, just published in Clinical Infectious Diseases.
I strongly encourage anyone who doubts the clinical benefits of curing HCV to read the full paper, but in essence the argument goes like this:
I will note that this isn't the first time a "systematic review" of an Infectious Disease treatment under the Cochrane name ended up with a surprising conclusion.
Remember this one on HIV treatment with TDF/FTC/efavirenz? The one which stated there was insufficient evidence to support its use, despite numerous randomized clinical trials documenting its efficacy? And its widespread adoption in clinical guidelines?
It may be hard to find today, since it was later withdrawn.
Paul E. Sax, M.D., is director of the HIV Program and Division of Infectious Diseases at Brigham and Women's Hospital in Boston.
|Cochrane Nonsense Review of HCV Treatment Misses Real Issues of Access to Care|
|Improvements in Mood and Energy After Successful HCV Treatments|
|Investigational Hepatitis C Drugs Show Promising Results|
No comments have been made.
The content on this page is free of advertiser influence and was produced by our editorial team. See our content and advertising policies.
|This Week in HIV Research: Quality of Life Is About More Than Viral Suppression|
|Gene Therapy in HIV Cure Research|
|Immediate HIV Treatment Has Little Impact on Risk of Future Drug Resistance|
|This Week in HIV Research: A Viral Prediction|
|This Week in HIV Research: You Don't Know Jak|
|Exploring HIV and Inflammation|