July 24, 2017
In this issue of TreatmentUpdate we discuss several emerging treatments for hepatitis C virus (HCV). Here is a brief guide to some drugs and the classes to which they belong.
Treatments for HCV available in high-income countries today are highly effective, with rates of cure generally greater than 90%. In the years ahead, even more powerful combinations of all-oral anti-HCV drugs, called direct-acting antivirals (DAAs), will become available to treat all major strains of HCV.
There are many steps that are needed within an HCV-infected cell so that copies of HCV can be made. These steps involve proteins and enzymes. A combination of drugs that target multiple proteins and enzymes makes for a more effective regimen than one single drug alone. HCV proteins and enzymes are targets of DAAs and serve as ways to group DAAs. This grouping is also used when sorting strains of HCV that are resistant to DAAs.
The enzyme called NS3 is part of a vital step in the production of copies of HCV. A protein called NS4A, made by HCV-infected cells, enhances the activity of NS3. Examples of drugs that work by attacking NS3 and/or NS4A include the following:
All of the above-listed drugs are called protease inhibitors.
The enzyme NS5B is part of another vital step in the creation of copies of HCV. NS5B inhibitors are divided into subclasses such as nukes (sofosbuvir) and non-nukes (dasabuvir, in Holkira Pak).
Researchers are not certain about the exact role of this protein, but it is critical to the production of HCV. Inhibitors of NS5A include the following:
Gotte M, Feld JJ. Direct-acting antiviral agents for hepatitis C: structural and mechanistic insights. Nature Reviews. Gastroenterology & Hepatology. 2016 Jun;13(6):338-51.
|Improvements in Mood and Energy After Successful HCV Treatments|
|Depression and Anxiety Not Barriers to HCV Treatment Success|
No comments have been made.
The content on this page is free of advertiser influence and was produced by our editorial team. See our content and advertising policies.
|'Female Condom' Gets a Genderless Rebrand From FDA|
|Virginia Governor Northam's Blackface Med School Antics Are the Reason Black Doctors Matter|
|Chlamydia and Gonorrhea Responsible for 10% of New HIV Infections Among MSM, According to New Study|
|For Our Stable HIV Patients, Why Are We Still Sending All These Lab Tests So Often?|
|Six Things Providers Should Know About HIV-Associated Neurocognitive Disorders|