Advertisement Covers CROI 2017


With Possibilities for Long-Acting HIV Treatment, Modern Science Creates Modern ART

February 23, 2017

Surveys indicate that the majority of people living with HIV would be happier with a monthly injection than a daily pill. At least five drug candidates are under development now because of their potential to be delivered in long-acting formulations, while existing daily antiretroviral drugs could also be "extendified" to be suitable for longer-acting formulations. Instead of intramuscular injections, the medicines could also be delivered through implants, as some long-acting contraception is now. Developing formulations for children is more complicated but not impossible. And in the end, in formulas that require less of the drug used over time, long-acting extended release antiretroviral medicines could be affordable in low and middle-income countries where they would knock down many existing barriers to treatment retention and adherence.

This is how, one by one, Dr. Charles Flexnor of Johns Hopkins University countered arguments against the feasibility of an approach to treatment that could transform the experience of living with HIV, and with that, efforts to control the virus and its spread. Flexnor, who invented the word "extendify" to express some of the possibilities he described last Thursday in Seattle, supported his points with science, including developments released in symposia and posters through the week.

For all the possibilities long-acting treatments will offer HIV care, he added, the biggest impacts of the advances toward their development will likely be on other diseases.

This excerpt was cross-posted with the permission of Science Speaks. Read the original article.

Related Stories

Top HIV Researcher Hails a Resurgent Antiretroviral Pipeline
Really Rapid Review -- CROI 2017, Seattle

This article was provided by Science Speaks. It is a part of the publication The 24th Conference on Retroviruses and Opportunistic Infections. Visit Science Speaks' website to find out more about their activities and publications.

No comments have been made.

Add Your Comment:
(Please note: Your name and comment will be public, and may even show up in
Internet search results. Be careful when providing personal information! Before
adding your comment, please read's Comment Policy.)

Your Name:

Your Location:

(ex: San Francisco, CA)

Your Comment:

Characters remaining:

Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.


The content on this page is free of advertiser influence and was produced by our editorial team. See our content and advertising policies.