The USPSTF recommends against routine serologic screening for genital herpes. The serologic test is lousy, with lots of false positives -- from the summary: "The positive predictive value may be as low as 75% for the biokit test and as low as 50% for HerpeSelect." As I've noted before, the recommendation against general screening probably won't apply to patients who come in requesting to be tested, where you can explain the pros and cons of the strategy.
Listerine is active against pharyngeal gonorrhea. At last, the answer to the challenges of the post-antibiotic era! And time to bring back this classic ad campaign (see poster), with slight modification: "He's not going to call -- but the Department of Public Health will!"
The investigational HCV treatment glecaprevir/pibrentasvir HCV has been submitted to the FDA. This protease inhibitor/NS5A inhibitor combination pill is a pan-genotypic approach that will be 8 weeks for treatment-naïve, 12 weeks for treatment-experienced or anyone with compensated cirrhosis. Clinical trials have included a wide range of patients, including those with HIV, advanced renal disease (including ESRD), and people who have failed current HCV therapy -- the last of these granting a Breakthrough Therapy Designation, meaning likely fast approval.
Results of anaerobic cultures rarely influence clinical management. In general, most of the patients with positive anaerobic cultures were already receiving therapy directed against the isolated bacteria, or there was no acknowledgement of the result at all. The authors call for anaerobic cultures to be ordered more selectively, which makes sense.
Finally, it's been a tough year for giants in music, especially if you're a fan of a certain age. We lost Prince, David Bowie, Leonard Cohen, Leon Russell, Keith Emerson, Sir George Martin ... and today, George Michael.
Here's a somewhat less-famous song of his (certainly less flashy -- here if you want that), with a nice late-Beatles/John Lennon quality to it, and lyrics quite appropriate to the times. Enjoy.
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