Heart, Kidney, Bone Disease Rates Higher With Than Without HIV Over 2003-2013
November 17, 2016
Prevalence of cardiovascular disease, renal impairment and fractures or osteoporosis was higher with than without HIV every year from 2003 through 2013 in a matched comparison of 87,000 people in a commercial insurance database. A similar comparison of 62,000 HIV-positive and negative Medicaid users found a higher prevalence of renal impairment with HIV in every study year and higher cardiovascular and bone disease rates in most years.
Increasing survival of antiretroviral-treated people with HIV has contributed to rising rates of serious non-AIDS diseases. To assess time trends of important comorbidities and to compare their prevalence in HIV-positive people and matched HIV-negative controls, researchers at the University of California, San Francisco, and other centers retrospectively analyzed patients in a commercial insurance database and a Medicaid database. Commercial or Medicaid patients had at least six months of continuous care before and after their earliest HIV diagnosis during the years 2003-2013, and all started antiretroviral therapy. For each HIV patient, the researchers selected up to three controls matched for insurance database, five-year age group, gender, race (Medicaid patients only), calendar year of index date and geographic region.
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