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21st International AIDS Conference (AIDS 2016)

News

Higher Rates of Eye Complications in HIV-Positive People on ART

October 1, 2016

A prospective South African study in 342 people looked at rates of optical complications and associations with HIV status and time on ART.

This group included: HIV-negative (n=105), HIV positive not on ART (n=16), HIV positive on ART for <12 months (short-term) (n=56) and HIV positive on ART for >36 months (long-term; n=165). All participants received full ophthalmic examination including fundoscopy.

Ocular disease was diagnosed in 218/342 people (64%). with HIV associated with a 3-fold higher rate or any ocular condition on (OR=3.1; 1.7-7.7; p< 0.001) and 2-fold risk of having more eye complaints (OR=1.9; 95% CI: 1.1-3.2, p=0.020), compared to HIV-negative participants.

Conditions affecting the external eye, anterior chamber or posterior chamber, but not the neuro-ophthalmic segment, were significantly more common among HIV-positive individuals (Table 1).

Within the HIV-positive group, after adjusting for age, longer ART use was associated with higher rates of clinical cataract (57% vs. 38%; aOR 2.2, p=0.01) and HIV retinopathy (30% vs. 11%; age-aOR 3.4, p<0.05).


Table 1: Eye Complications in HIV-Positive vs HIV-Negative People
  HIV+ on ART HIV-neg OR (95%CI) p-value
External Eye 40 (17%) 7 (7%) 2.8 (1.6 to 6.6) 0.015
Anterior Chamber 79 (33%) 18 (67%) 6.5 (0.8 to 5.0) 0.07
Posterior Chamber 58 (24%) 10 (10%) 3.1 (1.5 to 6.4) 0.001
Neuro-ophthalmic 8 (8%) 25 (11%) ns  


Reference

Peters R et al. Ocular conditions are more common among HIV-infected individuals using ART for an extended period of time. AIDS 2016, Durban. Poster abstract WEPE108
http://programme.aids2016.org/Abstract/Abstract/2476 (Abstract)
http://programme.aids2016.org/PAGMaterial/eposters/0_2476.pdf (PDF poster)




This article was provided by HIV i-Base. It is a part of the publication HIV Treatment Bulletin. Visit HIV i-Base's website to find out more about their activities, publications and services.
 


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