21st International AIDS Conference (AIDS 2016)


Higher Rates of Eye Complications in HIV-Positive People on ART

October 1, 2016

A prospective South African study in 342 people looked at rates of optical complications and associations with HIV status and time on ART.

This group included: HIV-negative (n=105), HIV positive not on ART (n=16), HIV positive on ART for <12 months (short-term) (n=56) and HIV positive on ART for >36 months (long-term; n=165). All participants received full ophthalmic examination including fundoscopy.

Ocular disease was diagnosed in 218/342 people (64%). with HIV associated with a 3-fold higher rate or any ocular condition on (OR=3.1; 1.7-7.7; p< 0.001) and 2-fold risk of having more eye complaints (OR=1.9; 95% CI: 1.1-3.2, p=0.020), compared to HIV-negative participants.

Conditions affecting the external eye, anterior chamber or posterior chamber, but not the neuro-ophthalmic segment, were significantly more common among HIV-positive individuals (Table 1).

Within the HIV-positive group, after adjusting for age, longer ART use was associated with higher rates of clinical cataract (57% vs. 38%; aOR 2.2, p=0.01) and HIV retinopathy (30% vs. 11%; age-aOR 3.4, p<0.05).

Table 1: Eye Complications in HIV-Positive vs HIV-Negative People
  HIV+ on ART HIV-neg OR (95%CI) p-value
External Eye 40 (17%) 7 (7%) 2.8 (1.6 to 6.6) 0.015
Anterior Chamber 79 (33%) 18 (67%) 6.5 (0.8 to 5.0) 0.07
Posterior Chamber 58 (24%) 10 (10%) 3.1 (1.5 to 6.4) 0.001
Neuro-ophthalmic 8 (8%) 25 (11%) ns  


Peters R et al. Ocular conditions are more common among HIV-infected individuals using ART for an extended period of time. AIDS 2016, Durban. Poster abstract WEPE108 (Abstract) (PDF poster)

This article was provided by HIV i-Base. It is a part of the publication HIV Treatment Bulletin. Visit HIV i-Base's website to find out more about their activities, publications and services.

No comments have been made.

Add Your Comment:
(Please note: Your name and comment will be public, and may even show up in
Internet search results. Be careful when providing personal information! Before
adding your comment, please read's Comment Policy.)

Your Name:

Your Location:

(ex: San Francisco, CA)

Your Comment:

Characters remaining:

Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.


The content on this page is free of advertiser influence and was produced by our editorial team. See our content and advertising policies.