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Spotlight Series on Hepatitis C

Information

HCV Medications by Drug Class

July/August 2016

CLASS

GENERIC/ COMMON NAME

BRAND NAME

FDA STATUS

GENOTYPE (FDA AND OFF-LABEL)

APPROVED FOR HIV/HCV CO-INFECTION?

MANUFACTURER

NS3/4A protease inhibitor

simeprevir, SMV

Olysio

APPROVED

1, 4

YES

Janssen

NS3/4A protease inhibitor

paritaprevir

Found in Viekira Pak and Technivie

APPROVED

Viekira Pak: 1
Technivie: 4

YES

AbbVie

NS3/4A protease inhibitor

grazoprevir

Found in Zepatier

APPROVED

1, 4

YES

Merck

Nucleotide NS5B polymerase inhibitor

sofosbuvir, SOF

Sovaldi
also found in Epclusa and Harvoni

APPROVED

1, 2, 3, 4

YES

Gilead Sciences

NS5A inhibitor

ledipasvir, LDV

Found in Harvoni

APPROVED

1, 4, 5, 6

YES

Gilead Sciences

NS5A inhibitor

daclatasvir, DCV

Daklinza

APPROVED

3

YES

Bristol-Myers Squibb

NS5A inhibitor

ombitasvir

Found in Viekira Pak and Technivie

APPROVED

Viekira Pak: 1
Technivie: 4

YES

AbbVie

NS5A inhibitor

elbasvir

Found in Zepatier

APPROVED

1, 4

YES

Merck

NS5A inhibitor

velpatasvir, VEL, (GS-5816)

Found in Epclusa

APPROVED

1, 3, 3, 4, 5, 6

NO

Gilead Sciences

Non-nucleoside NS5B polymerase inhibitor

dasabuvir

Found in Viekira Pak

APPROVED

1

YES

AbbVie

Nucleoside analog

ribavirin, RBV

Moderiba

APPROVED

1, 3, 3, 4, 5, 6

YES

AbbVie

Nucleoside analog

ribavirin, RBV

Ribasphere

APPROVED

1, 3, 3, 4, 5, 6

YES

Kadmon


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