Higher Rates of Five Major Non-AIDS Comorbidities After Age 50
August 8, 2016
Among eight serious non-AIDS comorbidities studied in a large Spanish HIV cohort, five developed more frequently in people 50 and older, including non-AIDS cancer and cardiovascular, kidney, bone and metabolic disease. Non-AIDS cancer developed in almost 14 of every 1000 older cohort members every year in this 2004-2014 analysis. Cardiovascular disease was diagnosed in people 50 and older six times more often than in younger people, according to the study, which was presented at AIDS 2016.
As antiretroviral therapy promotes longer survival of HIV-positive people, age-related illnesses account for growing shares of morbidity and mortality. Spanish researchers working with the multicenter, longitudinal CoRIS cohort described patterns of non-HIV morbidity according to age from 2004 to 2014. HIV-positive people seeking care at a participating center may enter CoRIS if they are older than 13 years and naive to antiretroviral therapy upon entry. The CoRIS team used medical records to determine the age distribution of cohort members from 2004 through 2014 and to calculate incidence per 1000 person-years for eight comorbidities: cardiovascular disease, kidney-associated events, liver-associated events, bone disease, psychiatric illness, metabolic illness, non-AIDS infections and non-AIDS malignancies.
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