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TheBodyPRO.com covers ASM/ICAAC 2016

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Update on Genetic Engineering for an HIV Cure

July 14, 2016

 3/8 

Modifying CD4 T Cells

Modifying CD4 T Cells

One of the first attempts at the knockout method was the use of zinc fingers to disable the CCR5 co-receptor in CD4 cells removed from someone living with HIV. The modified CD4 cells were then re-infused into that person. Clinical trials of this technique have shown long-term CD4 cell reconstitution and some decay in the latent reservoir of HIV-infected cells in study participants whose antiretroviral treatment (ART) controlled their viral load, but whose CD4 cell counts had remained low. Furthermore, total T cell counts increased and the modified T cells persisted long term in participants' bodies. A few participants who intentionally stopped ART also achieved some degree of viral control.

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This article was provided by TheBodyPRO.com. It is a part of the publication ASM Microbe 2016.
 


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Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

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