January 30, 2016
On 29 January 2016, the leading U.S. HIV treatment guidelines were updated online, strengthening the recommendation for early treatment.1
The main changes are to increase the rating for using ART irrespective of CD4 count to the highest A1 (strongest recommendation based on highest quality of scientific evidence). This change was based on results from the START and TEMPRANO studies.2,3
The recommendations are similarly strengthened (also to A1) for people diagnosed in early infection, noting "earlier ART initiation may result in less residual immune dysfunction during treatment, which theoretically may result in reduced risk of disease for decades to come."
While recognising some circumstances where treatment might be deferred the guidelines broad view access to treatment as an essential right for all patients, including irrespective of mental health, substance use and psychological issues.
The main recommendations are listed below.
|What's New in the U.S. HHS Antiretroviral Therapy Guidelines for Adults and Adolescents|
|Guideline on When to Start Antiretroviral Therapy and on Pre-Exposure Prophylaxis for HIV|
|Read the Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents (PDF)|
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