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HIV Antiretroviral Therapy: Past, Present and Future

September 14, 2015


HIV Antiretroviral Therapy: Past, Present and Future

Introduction to Antiretroviral Therapy

In the 1980s and early 1990s, a positive HIV test came with a grim prognosis. Yet in the last two decades, antiretroviral therapy has dramatically improved the health of HIV-positive individuals. Today, the life expectancy of HIV-positive people approaches that of the average population. In fact, for some North American patients, life expectancy exceeds the average.

As the medical community learned more about HIV, experts realized that a combination of different antiretrovirals was far more effective than a single drug. Today, most patients are treated with a cocktail of three drugs. The pharmaceutical industry successfully coformulated many of these drugs into combination pills, so patients no longer have to take dozens of pills per day.

There are now 15-million people on treatment around the world. Despite these gains, there is more to learn about the optimal combination of antiretroviral drugs, and guidelines are still evolving.

During a presentation at IAS 2015, Roy M. Gulick, M.D., presented a history of antiretroviral therapy, described the current treatment landscape and discussed new developments in the field.

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This article was provided by It is a part of the publication The 8th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention.

Reader Comments:

Comment by: Mwaijumba Samwel (Sumbawanga, Tanzania) Wed., Dec. 16, 2015 at 5:20 am UTC
can it be possible to find out the drug that has ability to remove the HIV's receptor on host cells?
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Comment by: Kazembe (Malawi , Africa) Fri., Oct. 2, 2015 at 9:26 am UTC
I have been on ARVs for over ten years. The greatest problem I face is stigma. There is also this condition known as neuropathy. I have also been a victim of fat loss on extremeties. Is there any medication for this condition. Can anyone please provide an answer.
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Comment by: Anonymous (Canada) Sun., Sep. 20, 2015 at 12:51 pm UTC
I have a feeling in researching more about resistance and new drugs to help those in those positions we may find some huge break throughs in HIV. Just a thought. Plus it also helps those that can't be on Stribild or Triumeq as they seem to be having a good run for the most part.
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Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.


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