News Maintenance HIV Regimen of Rilpivirine and Boosted Darunavir as Effective as Three-Drug Treatment in Early ResultsAugust 7, 2015 A presentation at the 2015 International AIDS Society conference in Vancouver reported 24-week results comparing a maintenance regimen of rilpivirine (Edurant) + boosted darunavir (Prezista/ritonavir) to a three-drug regimen of a boosted protease inhibitor and two NRTIs. This could offer some people a new treatment option should they experience significant adverse effects or resistance while on NRTIs. The PROBE study enrolled 60 people who had controlled HIV for more than six months. Everyone was on a boosted protease inhibitor regimen with either Truvada (emtricitabine/tenofovir) or Epzicom (abacavir/lamivudine). Half of them continued on their regimens while the other half switched to the maintenance regimen. Four out of five participants were men, average age was 48, and 1 out of 5 had had a previous AIDS diagnosis. No one had HIV that was resistant to rilpivirine and no one had current hepatitis B infection. The great majority (83%) had been on regimens with either boosted atazanavir (Reyataz) or boosted darunavir. The median time on HIV meds was 6.2 years, and the median number of regimens that had been used per person was 3. Average CD4 count was 623 and everyone had undetectable viral loads. SourceF Maggiolo, et al. Switch from PI/rtv + 2 nucleos(t)ides to RPV+DRV/rtv maintains HIV suppression and is well tolerated. IAS 2015, Vancouver, Canada. July 19â22, 2015. ![]()
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