September 22, 2017
Brand Name: Evotaz
Other Names: ATV/COBI, atazanavir sulfate/cobicistat
Drug Class: Combination Drugs
Evotaz can cause serious, life-threatening side effects. These include heart rhythm problems, severe rash, liver problems, gallbladder problems, and kidney problems.
Contact your health care provider right away if you have any of the following symptoms that could be signs of heart rhythm problems:
Contact your health care provider or go to the nearest hospital emergency room right away if you develop a severe rash or a rash with any of the following symptoms:
Some people taking Evotaz have had liver problems. People with a history of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection or who have elevated results on liver function tests may have an increased risk of developing new or worsening liver problems while taking Evotaz. Liver function tests may be done before and during treatment with Evotaz. Contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:
Contact your health care provider right away if you have any of the following symptoms that could be signs of gallbladder problems:
Evotaz, when taken with certain other medicines, can cause new or worse kidney problems, including kidney failure. Your health care provider should check your kidneys before and during treatment with Evotaz.
While taking Evotaz, it is important to keep all of your appointments with your health care provider.
Evotaz is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults. Evotaz is always used in combination with other HIV medicines.
PIs, such as atazanavir, block an HIV enzyme called protease. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking protease, PIs prevent HIV from multiplying and can reduce the amount of HIV in the body. Pharmacokinetic enhancers, such as cobicistat, are used in HIV treatment to increase the effectiveness of other HIV medicines. In Evotaz, cobicistat increases the effectiveness of atazanavir.
HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, including Evotaz, don't cut down on, skip, or stop taking them unless your health care provider tells you to.
Before taking Evotaz, tell your health care provider:
Evotaz comes in tablet form. Each tablet contains:
Take Evotaz according to your health care provider's instructions.
Take Evotaz once a day with food.
Always take Evotaz in combination with other HIV medicines.
If you take too much Evotaz, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take Evotaz, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)
If you miss a dose of Evotaz, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
Evotaz may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information.
Some side effects of Evotaz can be serious. Serious side effects of Evotaz include heart rhythm problems, severe rash, liver problems, gallbladder problems, kidney problems, and life-threatening drug interactions. (See the WARNING box above.)
Other possible side effects of Evotaz include:
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Evotaz. To learn more about possible side effects of Evotaz, read the drug label or package insert or talk to your health care provider or pharmacist.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at www.accessdata.fda.gov/scripts/medwatch/.
More information about Evotaz is available:
Main number: 800-332-2056
Patient assistance: 888-281-8981
The above Patient Version drug summary is based on the following FDA label(s): Tablet.
[Note from TheBody.com: This article was created by AIDSinfo, who last updated it on Sept. 22, 2017. We have cross-posted it with their permission.]
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