Top 10 Clinical Review


Top 10 HIV Clinical Developments of 2014

December 15, 2014

David Alain Wohl, M.D.

David Alain Wohl, M.D.

A year ago we were rubbing our hands in delight at shiny new integrase inhibitors and the first members of a merciful new generation of HCV therapies. Now, these seem like last year's holiday gifts -- first glee-inducing, then old hat.

Elvitegravir (Vitekta) and dolutegravir (Tivicay, DTG) have snipped their way into our HIV treatment prescribing gene, and along with raltegravir (Isentress) form a troika that dominates the U.S. Department of Health and Human Services HIV treatment guidelines.

Back at the end of 2013, we were struggling to spell the new HCV drugs sofosbuvir (Sovaldi) and simeprevir (Olysio). Today, the former has been glommed into a single-tablet wonder pill (sofosbuvir/ledipasvir, a.k.a. Harvoni) while the latter has to vie for relevance.

The past year also saw pre-exposure prophylaxis (PrEP) start to get the love that had long been withheld, but also the dimming of our hopes for eradicating HIV. Oh, and that Affordable Care Act thing got millions of people health insurance -- but not without some kicking and screaming.

These and other top stories make my list for 2014. It all happened so fast. Indeed, time flies like an arrow -- and, as you know, fruit flies like a banana.

Table of Contents

David Alain Wohl, M.D., is an associate professor of medicine in the Division of Infectious Diseases at the University of North Carolina and site leader of the University of North Carolina AIDS Clinical Trials Unit at Chapel Hill.

Copyright © 2014 Remedy Health Media, LLC. All rights reserved.

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Reader Comments:

Comment by: John V (Kansas City) Sun., Dec. 21, 2014 at 6:20 pm UTC
Can hiv be removed from sperm to be able to have successful invetro-fertilization and a birth of an hiv- child?
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Comment by: Devin (OH) Sun., Dec. 21, 2014 at 2:39 am UTC
This was not at all a list of the top 10 HIV developments of 2014. It was a very brief skimming of recent and not so recent HIV topics. "Dimming of hope for eradication..." very vague. Overall, a misleading title with an article that seems more like an introduction to the article. #endrant
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