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TheBodyPRO.com covers ICAAC 2014

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Long-Acting, Investigational Integrase Inhibitor Cabotegravir Shows Promise

October 17, 2014

Pharmacokinetic data for cabotegravir (CAB, GSK1265744), an integrase inhibitor in development, were presented by Susan L. Ford et al of GlaxoSmithKline at the recent 54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2014) in Washington, D.C. The drug is currently in phase 2 trials. Two versions of cabotegravir are being studied: an oral version that would be taken once a day and a long-acting version to be injected every four to 12 weeks. The 12-week injectable version is under development for pre-exposure prophylaxis (PrEP) in HIV-negative patients, while the oral version and injections every four or eight weeks are intended to keep HIV-positive patients virally suppressed (defined as < 50 copies/mL). The versions meant for maintenance therapy for HIV-positive people are supplemented by the non-nucleoside reverse transcriptase inhibitor rilpivirine (Edurant) or by TMC278 LA, a long-acting injectable version of rilpivirine currently under development.

An earlier trial, reported by William Spreen of GlaxoSmithKline at the 7th International AIDS Society Conference in Kuala Lumpur, Malaysia, in 2013 had shown that 5 mg or 30 mg of oral cabotegravir taken daily produced a 2-log10 decrease in HIV viral load, even as monotherapy. Both doses appeared to be equally efficacious and led to drug concentrations of > 90% inhibitory concentration (IC90) for both cabotegravir and rilpivirine. As TheBodyPRO.com's Warren Tong reported, "the hope is that [long-acting cabotegravir and rilpivirine] can act as long-lasting PrEP … or effective treatment for HIV-infected patients that could replace daily pills."

An interim proof-of-concept study named LATTE enrolled 207 virally suppressed HIV-positive participants in one of four arms: 10, 30 or 60 mg of daily oral cabotegravir boosted by 25 mg of rilpivirine or 600 mg of efavirenz (Sustiva, Stocrin). Week 48 results reported at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) in Boston seem promising, with 91%-96% of study participants in the cabotegravir arms remaining virally suppressed after 48 weeks, compared to 94% for those in the efavirenz arm.

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Ford reported now at ICAAC 2014 that the early development target for cabotegravir was a pharmacokinetic concentration of about four times protein-adjusted IC90 (PA-IC90) between doses. A population pharmacokinetic analysis of eight studies involving 346 HIV-positive and HIV-negative volunteers estimates an oral absorption rate constant of 2.16 and a long-acting absorption rate constant (KA LA) of 0.000454. Participants in these studies were overwhelmingly male (80%) and white (69%), with a median body mass index (BMI) of 25.5 kg/m2 (considered slightly overweight, according to the U.S. Centers for Disease Control and Prevention).

The analysis showed that KA LA was greater in men than women (0.000845 versus 0.000285) and decreased with increased BMI: KA LA was 35%-43% higher in those with a BMI in the 10th quantile and 20%-24% lower in those in the 90th quantile compared to the median BMI.

This pharmacokinetic population model predicts the following steady-state long-acting cabotegravir dosing regimens for intramuscular injections in the phase 2 trial:

  • 800-mg initial injection plus 400 mg injected every four weeks thereafter as maintenance therapy should yield a drug concentration of 3.35 µg/mL as maintenance therapy.
  • 800-mg initial injection plus 600 mg injected every eight weeks thereafter as maintenance therapy should yield a drug concentration of 2.02 µg/mL.
  • 800 mg injected every 12 weeks for PrEP should yield a drug concentration of 1.57 to 2.02 µg/mL.

All of these are higher than the 1.35-µg/mL drug concentration measured in the 10-mg daily oral cabotegravir regimen studied in the LATTE trial, in which more than 90% of participants remained virally suppressed.

The phase 2b clinical trials currently underway will show whether these predictions bear out.

Barbara Jungwirth is a freelance writer and translator based in New York.

Follow Barbara on Twitter: @reliabletran.




This article was provided by TheBodyPRO. It is a part of the publication The 54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2014).
 


Reader Comments:

Comment by: Cynthia (Las Vegas, NV) Fri., Oct. 24, 2014 at 5:02 pm UTC
I am a 46 year old, black, female that has been HIV Positive sense 1991. I want to participate in studies. I have taken medications for 4 or 5 years now. I haven't infected any of my partners I have had since I was diagnosed-at least that's what they have told me. I have been taking Reyetaz, norvir, and truvada medications. I havean undetetable status. I have 2 ex-boyfriends that still have feelings for me but are afraid to have sex with me. Can they take my meds as way of Prep (for 30 days) to avoid catching HIV from me? Will cabotegravir prevent them from catching it and for how long? How often do they take the drug before they need it again? How can they get it? can they acquire it through me and my insurance that will help me to protect others?
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Comment by: luther chimene (harare, zimbabwe) Wed., Oct. 22, 2014 at 1:05 am UTC
how do i participate. when i am staying in africa.
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Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

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