November 28, 2017
Brand Name: Triumeq
Other Name(s): ABC/DTG/3TC, abacavir sulfate/dolutegravir sodium/lamivudine
Drug Class: Combination Drugs
Triumeq can cause serious, life-threatening side effects. These include allergic reactions, buildup of lactic acid in the blood (lactic acidosis), and severe liver problems.
Triumeq contains abacavir, an HIV medicine. People who take abacavir-containing products, including Triumeq, may have a serious allergic reaction (hypersensitivity reaction) that can cause death. Your risk of this allergic reaction is much higher if you have a gene variation called HLA-B*5701. Your health care provider can determine with a blood test if you have this gene variation. If you get a symptom from two or more of the following groups while taking Triumeq, contact your health care provider right away to find out if you should stop taking Triumeq.
Your pharmacist will give you a Warning Card with a list of these symptoms. Carry this Warning Card with you at all times. If you stop Triumeq because of an allergic reaction, never take Triumeq or any other medicine that contains abacavir or dolutegravir again. If you take Triumeq or any other abacavir-containing medicine again after you have had an allergic reaction, within hours you may get life-threatening symptoms that may include very low blood pressure or death. If you stop Triumeq for any other reason, even for a few days, and you are not allergic to Triumeq, talk with your health care provider before taking it again. Taking Triumeq again can cause a serious allergic or life-threatening reaction, even if you never had an allergic reaction to Triumeq before. If your health care provider tells you that you can take Triumeq again, start taking it when you are around medical help or people who can call a health care provider if you need one.
Contact your health care provider right away if you have any of the following symptoms that could be signs of lactic acidosis:
Contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:
Some people taking Triumeq have had serious liver problems. People with a history of hepatitis B virus infection (HBV) or hepatitis C virus infection (HCV) may have an increased risk of developing new or worsening liver problems while taking Triumeq.
If you have both HIV and HBV infection and take Triumeq, your HBV infection may get worse (flare up) if you stop taking Triumeq. To help avoid this, take Triumeq exactly as prescribed. Do not run out of Triumeq or stop taking Triumeq without talking to your health care provider.
Worsening of liver disease (sometimes resulting in death) has occurred in people with both HIV and HCV who were taking HIV medicines and also being treated for HCV infection with interferon with or without ribavirin. If you are taking Triumeq and interferon with or without ribavirin and you have any new symptoms, tell your health care provider.
Liver problems have also occurred in people taking Triumeq who have no history of liver disease. Liver function tests may be done before and during treatment with Triumeq.
Do not take Triumeq if you take dofetilide (a medicine used to treat an irregular heartbeat). Taking Triumeq and dofetilide can cause side effects that may be life threatening.
While taking Triumeq, it is important to keep all of your appointments with your health care provider.
Triumeq is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children weighing at least 88 pounds (40 kilograms). Triumeq can be used alone as a complete treatment regimen or with other HIV medicines.
Triumeq contains the following three different medicines combined in one pill:
Integrase inhibitors block an HIV enzyme called integrase, and NRTIs block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking integrase and reverse transcriptase, the three drugs in combination prevent HIV from multiplying and can reduce the amount of HIV in the body.
Triumeq is not for use by itself in people who have or have had resistance to abacavir, dolutegravir, or lamivudine.
HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, including Triumeq, don't cut down on, skip, or stop taking them unless your health care provider tells you to.
Before taking Triumeq, tell your health care provider:
Triumeq comes in tablet form. Each tablet contains:
Take Triumeq according to your health care provider's instructions.
Take Triumeq with or without food. If you are taking any other medicines, carefully follow instructions on how to take them with Triumeq.
If you take too much Triumeq, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take Triumeq, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)
If you miss a dose of Triumeq, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and take the next dose at your regular time. Do not take two doses at the same time to make up for a missed dose. If you are not sure about your dosing, call your health care provider.
Triumeq may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information.
Some side effects of Triumeq can be serious. Serious side effects of Triumeq include allergic reactions, buildup of lactic acid in the blood (lactic acidosis), and severe liver problems. (See the WARNING box above.)
Other possible serious side effects of Triumeq include:
The most common side effects of Triumeq include trouble sleeping, headache, and tiredness.
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Triumeq. To learn more about possible side effects of Triumeq, read the drug label or package insert or talk to your health care provider or pharmacist.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at www.accessdata.fda.gov/scripts/medwatch/.
More information about Triumeq is available:
Main number: 877-844-8872
Patient assistance (ViiV Connect): 844-588-3288
The above Patient Version drug summary is based on the following FDA label(s): Tablet, film coated.
[Note from TheBody.com: This article was created by AIDSinfo, who last updated it on Nov. 28, 2017. We have cross-posted it with their permission.]
No comments have been made.
The content on this page is free of advertiser influence and was produced by our editorial team. See our content and advertising policies.