"3D" Combo Drug Cures 99% of Hepatitis C, Without Interferon and Ribavirin
March 6, 2014
A 12-week course of three direct-acting antivirals cured at least 99% of previously untreated people with genotype-1b hepatitis C infection, according to a study presented by Rajender Reddy, M.D., at CROI 2014 in Boston.
The phase-3 study, known as PEARL III, followed 419 treatment-naive patients with hepatitis C genotype 1b (the most common genotype of hepatitis C). All participants received the triple-drug, fixed-dose combination known as "3D" for 12 weeks and were randomized to also receive either ribavirin (210 patients) or a placebo (209 patients).
The researchers concluded that for patients with genotype-1b hepatitis C, a 12-week course of "3D" is highly effective and safe, and if approved by regulatory agencies could become the first interferon-free and ribavirin-free combination for hepatitis C. AbbVie, which is developing the drug, plans to submit it for U.S. Food and Drug Administration approval later this year.
Warren Tong is the research editor for TheBody.com and TheBodyPRO.com.
Follow Warren on Twitter: @WarrenAtTheBody.
Copyright © 2014 Remedy Health Media, LLC. All rights reserved.
This article was provided by TheBodyPRO.com. It is a part of the publication The 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014).
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