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Building a Better HIV Drug: Nano-Formulated Medicines

December 18, 2013


Limitations of Long-Acting Formulations

Limitations of Long-Acting Formulations

While having long-acting drugs will reduce the frequency of doses, there are some limitations, Owen noted.

For one thing, treatment interruptions won't be possible, which is particularly a concern when the need arises to manage an acute event (such as surgery or coinfection), pregnancy or the patient's desire to take a drug holiday.

There also are no strategies yet for how to manage drug-drug interactions between long-acting antiretrovirals. Furthermore, we don't yet know how appropriate long-acting drugs would be for patients with high viral loads. But hopefully with more research and trials, these concerns can be addressed.

This article was provided by It is a part of the publication The 14th European AIDS Conference (EACS 2013).

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