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6 Approaches to Improving Long-Term HIV Treatment Adherence

December 3, 2013


Patient-Based Strategies

Patient-Based Strategies

Empowering patients to be their own adherence advocates can itself be an effective intervention, Ammassari suggests. Active patient self-reports of adherence should be ascertained in a simple, nonjudgmental, routine and structured way. This is associated with better viral load responses and can help identify barriers -- although self-reports do tend to overestimate adherence.

Of course, an intervention such as this needs to have the patient on board. A patient's intention to adhere was significantly predictive of self-reported adherence to treatment, according to study results by A. Nelsen, M.D., and colleagues.

In terms of behavioral interventions, there have been many studies, but no results have been promising enough to implement on a clinical level. Out of 16,172 U.S. studies conducted between 1996 and 2011 that were intended to improve adherence, only 10 were identified as evidence-based interventions; others failed to meet the efficacy criteria primarily due to null findings, small sample sizes or low retention rates, according to a meta-analysis by Mahnaz R. Charania, Ph.D.

This article was provided by It is a part of the publication The 14th European AIDS Conference (EACS 2013).


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