Print this page    •   Back to Web version of article

Dolutegravir in Treatment-Experienced People Who Have Not Previously Used an Integrase Inhibitor

By Sean R. Hosein

August 2013

Researchers in Australia, Latin America, North America, Europe, South Africa and Taiwan recruited 715 HIV-positive people for a double-blind, placebo-controlled study comparing regimens containing dolutegravir to regimens containing raltegravir. All participants had previously used anti-HIV therapy (commonly called ART or HAART) and nearly half of participants had a history of AIDS. Moreover, according to researchers, nearly half of participants had HIV that was resistant to "at least one drug in each of three or more [classes of drugs]."

After one year, researchers found that, in general, a dolutegravir-containing regimen was statistically superior to a raltegravir-containing regimen. This finding was driven by virologic results with fewer dolutegravir users developing treatment failure.

The average profile of participants at the start of the study was as follows:

Advertisement

Researchers referred to the drugs used in addition to dolutegravir or raltegravir as the "background" regimens. Drugs commonly used as background regimens in this study were as follows:

Participants were randomly assigned to receive dolutegravir or raltegravir, so that their regimens were as follows:

The double-blind, placebo-controlled part of the study lasted for 48 weeks. After this, participants who received dolutegravir and who completed the first 48 weeks of the study were told which drug they received. They were also offered continued treatment with dolutegravir and will be monitored every 12 weeks.


Results -- Changes in Viral load

In both study groups the proportion of participants with a viral load less than 50 copies/ml rose sharply during the first four weeks, then less so over the subsequent four weeks. After the eighth week of the study, the proportion of participants with a low viral load (less than 50 copies/ml) remained relatively stable. The swiftness of the initial decline in viral load is something that is associated with integrase inhibitors.

The proportion of participants with a viral load less than 50 copies/ml at the 48th week of the study was distributed as follows:

Researchers performed calculations and concluded that dolutegravir's anti-HIV effect was "statistically superior" to that of raltegravir.


Why the Difference?

Both dolutegravir and raltegravir are good drugs when used as part of combination therapy. However, the finding of statistical superiority favouring dolutegravir arose according to the researchers because virologic failure "occurred earlier and more frequently in [participants who took raltegravir (12%) compared to participants who took dolutegravir (6%)]."

Furthermore, 42% of 45 participants who took raltegravir and who developed virologic failure were termed "non-responders" by researchers. Essentially, non-responders did not have a major decrease in viral load and were not able to have their viral load fall below the 400-copies/ml mark. This contrasts with only 10% of 21 participants who took dolutegravir and who developed virologic failure and who were also virologic non-responders.


Darunavir Plays a Role

Darunavir is a powerful protease inhibitor. When taken with a small dose of ritonavir, darunavir can be taken once daily. When researchers analysed the data from Sailing among participants who took darunavir-ritonavir with dolutegravir or raltegravir, dolutegravir's anti-HIV effect was found to be roughly equivalent in potency to raltegravir. However, bear in mind that the majority of participants did not use darunavir.

Complications and Side Effects

Rates of side effects were similar whether participants were taking dolutegravir or raltegravir. There are at least two possible reasons for this. First, as a class, integrase inhibitors are generally well tolerated. Secondly, the background regimens for nearly all participants were combinations of protease inhibitors. These drugs can cause a range of side effects, mostly affecting the gastrointestinal tract (nausea, vomiting, diarrhea). Such side effects may have dwarfed any, more minor side effects that may have occurred with exposure to integrase inhibitors. Researchers noted that, in general, side effects were mostly of mild-to-moderate intensity.

No deaths occurred among participants who received dolutegravir. Although there were three deaths among raltegravir users, investigators found that none were caused by raltegravir (two cases of unrelated cancer and one case of multi-organ failure).

Some commonly reported side effects appear below. Bear in mind that many participants were taking complex regimens, so it is difficult to connect exposure to the study drugs with specific side effects.

Advertisement

Diarrhea

Lung/throat infections

Headache

Vomiting

Fatigue

Rash

Joint pain


Severely Abnormal Lab Test Results

ALT (alanine aminotransferase -- a liver enzyme)

Cholesterol

Creatinine

Higher-than-normal blood sugar

Elevated levels of creatine phosphokinase (CPK)


For the Future

Dolutegravir is expected to be approved as part of combination therapy for HIV-positive people in the U.S. by September and in Canada later this year.

A future issue of TreatmentUpdate will explore the issue of kidney health and dolutegravir.


Reference

Cahn P, Pozniak A, Mingrone, et al. Dolutegravir is superior to raltegravir in ART-experienced, integrase-naïve subjects: week 48 results from Sailing (ING111762). In: Program and abstracts of the 7th IAS Conference on Pathogenesis, Treatment and Prevention, 30 June to 3 July, 2013, Kuala Lumpur, Malaysia. Abstract WELBB03.




This article was provided by Canadian AIDS Treatment Information Exchange. It is a part of the publication Treatment Update. You can find this article online by typing this address into your Web browser:
http://www.thebodypro.com/content/72610/dolutegravir-in-treatment-experienced-people-who-h.html

General Disclaimer: The Body PRO is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through The Body PRO should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, consult your health care provider.