June 14, 2013
Results of a study of patients with hepatitis C virus (HCV)/HIV coinfection indicated that therapy with interferon and ribavirin provided clinical benefit even in those who relapsed after treatment. The researchers evaluated 1,599 patients from the Spanish HIV/AIDS study GESIDA 3603, which included patients coinfected with HCV and HIV who were treated with interferon and ribavirin at 19 Spanish medical centers.
At 24 weeks posttreatment, 584 patients had sustained virologic response (SVR), while 765 had no response and 250 relapsed after the end of treatment. There were associations between SVR and having received pegylated interferon, low HCV RNA levels, lack of advanced fibrosis, daily alcohol intake below 50 grams, and HCV genotype 2 or 3. Patients with SVR had lower overall liver-related, AIDS-related, and non-AIDS/nonliver-related mortality rates compared with the other groups. Those who relapsed had lower overall and liver-related mortality rates than nonresponders. Risk for liver-related events (decompensation, liver cancer, liver transplant, and liver-related death) was lowest in the SVR group and lower among relapsers than nonresponders. Also, patients who experienced SVR had less liver stiffness than the other groups and relapsers had less liver stiffness than nonresponders.
According to researcher Juan Berenguer, M.D., from the infectious disease and HIV unit at Hospital General Universitario Gregorio Marañón in Madrid, findings suggested that for patients with HCV/HIV coinfection, viral relapse after HCV treatment provided some clinical benefits.
The full report, "Clinical Effects of Viral Relapse After Interferon Plus Ribavirin in Patients Co-Infected With Human Immunodeficiency Virus and Hepatitis C Virus," was published in the Journal of Hepatology (2013; 58 (6): 1104-1112).
No comments have been made.
The content on this page is free of advertiser influence and was produced by our editorial team. See our content and advertising policies.
|A Review of Late-Stage HIV Antiretroviral Candidates at IDWeek 2017|
|PrEP Prescriptions Rise Sharply, but Unequally, in New York City|
|How to Reverse Implicit Bias in HIV Care: 6 Steps to Take Today|
|Free Your (and Carl's) Mind: An Open Letter to Anthony Fauci About HIV Prevention Research Priorities|
|This Week in HIV Research: Injectable PrEP Shows Promise in New Study|
|Ignorance About PrEP Is Common Among Health Care Providers, Studies Suggest|