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Liquid Injectable Silicone Effective, Safe for Treating HIV Patients With Facial Lipoatrophy: Study

June 3, 2013

Research in British Columbia, Canada, indicates that liquid injectable silicone administered properly has potential as a safe, effective, natural feeling treatment for patients with HIV-associated facial lipoatrophy (FLA). The researchers tested liquid injectable silicone because temporary filler treatments were not permanent and could result in high costs.

Alastair Carruthers, FRCPC, clinical professor of the department of dermatology and skin science at the University of British Columbia, Vancouver, and colleagues studied 20 Caucasian patients (18 men) ages 34-58 with HIV-associated FLA. The patients received a maximum of 2 milliliters (mL) of 1,000-cSt highly purified medical-grade liquid injectable silicone at each session, with a maximum of six sessions. The researchers evaluated safety, efficacy, injection volumes, and patient satisfaction at 9, 12, and 18 months post-treatment. Eighteen patients received six sessions, one had five, and one had four sessions. After the fifth session, 15 patients had complete correction, 17 had complete correction after 9 months, and most patients maintained correction at 18-month follow-up. No patients reported persistent adverse events.

The researchers concluded that that highly purified 1,000-cSt liquid injectable silicone, when administered by microdroplet technique of no more than 2mL per visit appeared to be promising and safe for treating HIV-associated FLA. They acknowledged that the study was limited by its small population size and was noncomparative and nonmasked. Carruthers stated that the small study justified a longer, larger study.

The full report, "HIV-Associated Facial Lipoatrophy Treated With Injectable Silicone Oil: A Pilot Study," was published online in the Journal of The American Academy of Dermatology (2013; doi:10.1016/j.jaad.2013.03.025).

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Reader Comments:

Comment by: vipin (singapore) Mon., Jan. 6, 2014 at 2:45 am EST
Its amazing, looking at the time and effort you put into your blog and detailed information you provide. I'll bookmark your blog and visit it weekly for your new posts.
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Comment by: William Raynor (Asheville NC) Wed., Jun. 12, 2013 at 8:28 pm EDT
Hi, I saw this article and I am interested in knowing about this treatment about facial Lipodystophy which I have had for a long time,and have checked in the past for treatment and unfortunely my insurance did not cover it,is this treatment covered by medicare or medicaid? this is something I have struggled with and concerned for years.although I have been HIV-positive for almost 30 years,I just live with it among other health issues I have,if someone could respond to this question,I'd appreciate it..Thank you.
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Comment by: Raymond K. (Seattle,WA) Fri., Jun. 7, 2013 at 3:04 pm EDT
If they need more subjects, I would be most interested
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Comment by: vetteman911 (Orlando, FL) Thu., Jun. 6, 2013 at 2:00 pm EDT
I have extreme FLA. Recently went to two consultations with what is well known as "the best" Plastic Surgeon, with excellent recommendations. Was scheduled to have my first injections... when I got a call. See the PA told me that she didn't see why they couldn't place the Procedure Codes on my Itemized Bill, so then I could get reimbursed from Medicare and/or my Secondary Insurance Policies. Not so fast... my life was shattered!! The week I was to have the procedure started, when the call came through, the PA who was actually going to do the injections, told me that the actual doctor got wind of what we were doing with putting the Procedure Codes on MY bill, for reimbursement, and he said NO!! His practice can not take me on!! Oh, I was so disappointed. This guy and his practice was/is the best around. So now I am back to square one, starting all over again. But, after reading this article, I love what I'm hearing. I really wasn't looking forward to this constant and continuing expense. My first bill would have well over $5,000.00. Does anyone know how I could get hooked up with this study, maybe find more information, or to become a part of it. Like I said, my wasting is extreme. I have been on meds for over 25 years, which as you all know take a toll on all of us physically and mentally. Thanking any of you in advance for the help you may be able to offer.

Bill
vetteman911@cfl.rr.com
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