Advertisement
Advertisement

TheBodyPRO.com covers CROI 2013

Results From Multi-Dose Vorinostat Trial

Selected Research Highlight From CROI 2013

March 25, 2013

Sharon Lewin from Monash University in Melbourne debuted data from the first multidose trial of vorinostat (also known as SAHA) as a potential anti-HIV latency drug (abstract, webcast -- ninth in session). Consistent with results published by David Margolis from a single-dose trial, expression of HIV RNA significantly increased among the twenty participants after 14 days of vorinostat. However, there was no evidence for reduction in the size of the latent HIV reservoir, suggesting that additional approaches will be needed to facilitate the elimination of the infected cells. As expected, vorinostat side effects were more prevalent as a result of the multiple dosing, particularly fatigue and lethargy.

Richard Jefferys is the coordinator of the Michael Palm HIV Basic Science, Vaccines & Prevention Project Weblog at the Treatment Action Group (TAG). The original blog post may be viewed here.




This article was provided by Treatment Action Group. It is a part of the publication Michael Palm HIV Basic Science, Vaccines & Prevention Project Weblog.
 


No comments have been made.
 

Add Your Comment:
(Please note: Your name and comment will be public, and may even show up in
Internet search results. Be careful when providing personal information! Before
adding your comment, please read TheBody.com's Comment Policy.)

Your Name:


Your Location:

(ex: San Francisco, CA)

Your Comment:

Characters remaining:


Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

Advertisement