How Can "JAK Inhibitors" Help Salvage Patients and the Search for an HIV Cure?

An Interview With Raymond Schinazi, Ph.D., D.Sc.

January 15, 2013

Nelson Vergel, B.S.Ch.E., M.B.A.

Nelson Vergel, B.S.Ch.E., M.B.A., is a leading HIV treatment advocate, author and founder of the Body Positive Wellness Center in Houston, Texas.

 < Prev  |  1  |  2  |  3 

I guess you're thinking about proceeding with human pilot studies, too. How is that going to happen?

I've already spoken with officials at the NIH [U.S. National Institutes of Health] as well, and to physicians who specialize in viral eradication. They're trying everything but the kitchen sink. The fact that this drug is already approved and under controlled conditions, we're planning to do a carefully designed clinical study. We want to do this in monkeys first as a proof-of-concept, but I think there's enough interest among some of the physicians I've talked to to perhaps do a small pilot study and see whether indeed this works the way it's supposed to. This is all very new stuff. So we're gearing up toward that and we hope that we will get our protocol approved so we can actually try it in humans.

It's also a question of getting some funding for that study, but it's a small number of patients because it's a high risk, high return and I don't think the drug on its own is going to be enough. We need to basically find patients who are already virus suppressed on HAART and add on this molecule for a few months and eventually take off the other medication and see what happens; see if the virus gets reactivated or reactivation is delayed. You have to select very carefully the population of patients that you're going to use for the study; they shouldn't be very sick and we have to be careful, because resistance could be an issue, especially in patients who've had HIV for a long time. So you don't want to withdraw treatment unnecessarily. The patients have to be monitored very carefully. We also have to develop better methods for detecting virus at very low levels. It's something that we can do now with the technology available for that purpose. That's why I wanted to do this in monkeys first, but as I said, some of my colleagues indeed would like to go straight into humans.

Will the funding come from the NIH or from any of the companies like Pfizer? Are they interested in this kind of indication?

I cannot talk, because I have a CDA [confidential disclosure agreement] with the company. I cannot discuss which company. All I can tell you is I'm working with a company at this stage, trying to look at better drugs that would have lower toxicity and be safer to use specifically for this purpose. I don't know whether they have funds for this study. We have other resources and for a pilot study it will not be costly.

This transcript has been edited for clarity.

 < Prev  |  1  |  2  |  3 

Get email notifications every time HIV Care Today is updated.

Copyright © 2011-2016 Remedy Health Media, LLC. All rights reserved.

See Also
No Proof of New HIV Cure, Despite Headlines -- Here's What We Know
The Only Cases of HIV Cure or Remission
Beyond the Berlin Patient: How Researchers Are Now Trying to Cure More HIV-Positive People (Video)
What Would an HIV Cure Mean for You?

Reader Comments:

Comment by: Robert Neal (Philadelphia, PA) Wed., Feb. 6, 2013 at 11:11 am UTC
I have been on meds since 1994. Much resistance but currently doing well on a very potent regimen of 4 antiretrovirals, however I look very forward to a safe (functional) cure that would eliminate the need to to take daily medications. Nelson keep up the good work,take care
Reply to this comment

Comment by: michael (los angeles) Sat., Jan. 26, 2013 at 4:24 am UTC
where do i sign up? i can think of no better reason to take a HAART holiday than being a participant in this new approach. have only been taking atripla (or sustiva/travada in the beginning few months) since '08 and have been undetectable since (well, by kaiser's measuring standards, there are times that it is less than 48 copies detected which they don't consider undetectable....they only call it undetectable when their machines can find no trace at all within the 48 copies or less range if that makes any sense).....but the last few years or so, they say i am undetectable.
Reply to this comment

Add Your Comment:
(Please note: Your name and comment will be public, and may even show up in
Internet search results. Be careful when providing personal information! Before
adding your comment, please read's Comment Policy.)

Your Name:

Your Location:

(ex: San Francisco, CA)

Your Comment:

Characters remaining:


The content on this page is free of advertiser influence and was produced by our editorial team. See our content and advertising policies.