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Spain: Inactivated Virus Shows Promise Against HIV

January 4, 2013

A new study shows that injecting heat-inactivated HIV can arouse the immune system in some patients, allowing them temporary freedom from drugs. Ultimately, this approach could lead to a long-term treatment of HIV.

Researchers extracted HIV and a sampling of immune system cells (dendritic cells) from 36 patients. The researchers used heat to inactivate the HIV of 22 randomly selected patients, and then administered the patients a vaccine comprised of their own dendritic cells and their inactivated HIV. In 12 of the 22 patients, virus levels dropped 90 percent over 12 weeks.

According to study co-author Felipe Garcia, an infectious disease physician at the University of Barcelona, the combination of dendritic cells and inactivated HIV stir the immune system to attack the live virus circulating in patients' bodies. In the treated patients, the immunity to HIV diminished and virus levels increased eventually. After 48 weeks only three participants who received the experimental vaccine maintained the 90-percent drop in virus levels. The patients in the control group who received their own unchanged HIV and dendritic cells showed little benefit. Prior to the study, all participants were being treated with standard antiretroviral therapy.

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Garcia suggests that a therapeutic vaccine would still be beneficial, even if it offered only long-lasting temporary effects rather than completely eradicating HIV from the body. He stated that dropping the virus down to extremely low levels may mean patients would not need drugs, would not show symptoms, and would not be likely to transmit the disease to others. He noted that people with these low levels of virus (elite controllers) already exist, in the less than 1 percent of people who have been infected with HIV for years, but whose immune systems suppress the virus.

The study, "A Dendritic Cell–Based Vaccine Elicits T Cell Responses Associated with Control of HIV-1 Replication," was published in the journal Science Translational Medicine (2013; 5 (166): 166ra2).

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Reader Comments:

Comment by: Ajay (India) Fri., Jan. 18, 2013 at 12:46 am EST
It's good to know that promising approaches towards cure are coming up. Maybe soon we'll have a potential cure or a vaccine to prevent further transmission. Congratulations for this discovery and good luck for further research.
I'm a post graduate in Microbiology, quite interested in HIV research as I'm myself positive. I never got an opportunity in this foray. If I get a chance I'll certainly like to work in cure research.
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Comment by: Tom (Illinois) Sun., Jan. 6, 2013 at 7:37 am EST
I'd like to see a study of a vaccine like this given along with supplemental amounts of the Vitamin-D (hormone) carrier molecule (GcMAF) which is destroyed by HIV.

Complexed into the gp120 protiens of HIV is an enzyme that detroys the carrier molecule (GcMAF) for the hormone (not really a vitamin) "Vitamin-D".

http://www.ncbi.nlm.nih.gov/pubmed/8573395

A small peer-reviewed published study demonstrated that the immune systems of young, healthy, recently HIV-infected patients could clear their HIV infections with supplemental amounts of GcMAF.

http://onlinelibrary.wiley.com/doi/10.1002/jmv.21376/abstract

Here's an E-book about GcMAF:

http://www.timsmithmd.com/


As you can read from the peer-reviewed document in the 2nd link, 15 HIV+ Japanese patients were (at a minimum *** functionally ***) cured of their HIV infections twelve years ago with (no more than) 18 weeks of supplemental amounts of human-sourced GcMAF. That paper was published in early 2009. But, a 2006 FOCIS meeting abstract informed us of this research much earlier.

The peer-reviewed paper was quickly followed by a 2009 FOCIS meeting abstract which claimed that an additional 24 patients were cured. In that study GcMAF was made from both human-source Gc protein and a cloned and truncated Gc protein mimic.

What are we waiting for?
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Replies to this comment:
Comment by: Jose (Minnesota) Sun., Jan. 27, 2013 at 2:40 pm EST
This supplement you are and everything you are talking about, can you only get it from a physician? Or, can you get it somewhere else? Im hiv+ was detected just about two months after I was infected and got on treament about 5 months after I got infected. I've always been healthy and never got any synthoms. So this thing you are talking about GIVES ME A BIG HOPE.


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