Shaking the Status Quo: 2012 HIV/AIDS Conference Research Highlights
By Myles Helfand and Warren Tong
November 15, 2012
Antiretrovirals in Development
As soon as the approval of the long-awaited "quad" (elvitegravir/cobicistat/emtricitabine/tenofovir, Stribild) added a valuable new integrase inhibitor and boosting agent (as well as a new efavirenz [Sustiva, Stocrin] alternative) to the first-line therapy pantheon, eyes almost immediately turned to seek out the next exciting drug in the antiretroviral pipeline.
It didn't take long for those eyes to settle on dolutegravir, an integrase inhibitor whose safety and efficacy profile impressed in early clinical trials.
The bar continues to climb for HIV antiretrovirals, with expected efficacy rates for first-line regimens now nearing the 90% mark -- a level almost unthinkable less than a decade ago. And yet the pipeline, while arguably not as rich as it was several years ago, continues to feature promising drugs, with dolutegravir as the present-day vanguard.
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Wed., Jan. 9, 2013 at 10:38 am EST
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