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PDFReyataz and Kidney Stones
November/December 2012
Reyataz, one of two preferred HIV protease inhibitor (PI) medications under U.S. treatment guidelines, is associated with the risk of kidney stones and other potential renal abnormalities. According to Japanese researchers, people taking Norvir-boosted Reyataz developed kidney stones 10 times more frequently than those taking other PIs. Kidney stones were diagnosed in 31 of 465 individuals on boosted Reyataz vs. four out of 775 patients taking another PI.
Furthermore, six of the 18 people who continued taking boosted Reyataz after developing kidney stones experienced new ones. Lead researcher Yohei Hamada, M.D., pointed out that most participants were of East Asian origin and, "Thus, it will be important to investigate the association between [Norvir-boosted Reyataz] and the development of renal stones in other populations."
The study was conducted at the National Center for Global Health and Medicine in Tokyo.
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Reader Comments:
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After initially having some fairly acute pain some five months ago, I recently had a recurrence of mild pain and discovered I had two kidney stones (I've been on norvir and reyataz for 5+ years). A CT scan showed one 9x4mm and one 5x4mm, both at the entrance to the bladder (having already passed the length of the ureter). Just as I was being scheduled for lithotripsy, someone told me about Chanca Piedra (which translates as "stone breaker"), an herb that has been used for kidney stones for many years. Since I wasn't experiencing any acute pain and was going to have to wait 2 weeks for the lithotripsy, I began taking the herb (in tincture form), and nine days later I passed what looked like part of a stone--a fragment some 4x5mm. There was no pain at all. I kept taking the tincture, and about ten days later I passed another stone, again without any pain, about 8x5mm. I had already cancelled the lithotripsy after the first stone passed, and now consider that I'm most likely stone free. I'll have another scan in a month or so to confirm. Obviously I highly recommend trying Chanca Piedra! (And my doctor has switched me off of Reyataz.)
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