October 31, 2012
Researchers at Copenhagen University, Denmark, conducted a systematic review and meta-analysis of randomized controlled trials to determine whether antiviral therapy for treatment of the hepatitis C virus (HCV) infection reduces the risk of developing hepatocellular carcinoma (liver cancer). Researchers performed electronic searches of the Cochrane Library, PubMed, EMBASE, and Web of Science for studies that met their requirements. They performed additional searches, including scanning reference lists from relevant papers on chronic hepatitis C and liver cancer, conference proceedings, and the World Health Organization Trial Search Portal.
Eight randomized trials, and five prospective cohort studies comparing antiviral therapy (interferon or pegylated interferon alone or with ribavirin), placebo, or no intervention were analyzed. The treatment time varied from 1 to 5 years and follow-up ranged from 2 to 8.7 years.
The results indicate that antiviral therapy may reduce the risk of liver cancer in hepatitis C-related fibrosis and cirrhosis. The effect may be seen irrespective of the virological response, but is more pronounced among virological responders compared with non-responders.
The study was reported online in the journal BMJ Open 2012;2:e001313 doi:10.1136/bmjopen-2012-001313.
10.22.2012; Nina Kimer; Emilie Kristine Dahl; Lise Lotte Gluud; Aleksander Krag
No comments have been made.
The content on this page is free of advertiser influence and was produced by our editorial team. See our content and advertising policies.
|No Increased Risk of Liver Cancer After Hepatitis C Treatment With Direct-Acting Antivirals|
|This Week in HIV Research: Another Person Possibly Cured of HIV; and Long-Acting Rilpivirine Suppresses HIV in Rectal Tissue|
|This Week in HIV Research: HIV-Related Inflammation May Be Irreversible; and Genetically Engineered T-Cells Resist HIV|
|How Close Are We to a Cure for HIV? A Q&A With HIV Cure Scientific Superstars|
|Dolutegravir and the Central Nervous System: A Top HIV Clinical Development of 2016|