October 5, 2012
A study by E. Christina Persson of the National Cancer Institute, Rockville, MD, and colleagues indicated that there is an increased risk of cancers of the stomach and esophagus in people with AIDS.
The researchers analyzed data from 596,955 people from the HIV/AIDS Cancer Match Study, which links data from 1980 to 2007 for 16 US population-based HIV and AIDS cancer registries. They compared stomach and esophageal malignancies in people with AIDS with those of the general public and evaluated the risks of different histological and anatomic subtypes of carcinomas and non-Hodgkin lymphomas of the stomach and esophagus in people with AIDS.
Results show that people with AIDS have 69 percent and 44 percent increased risks of esophageal and stomach carcinomas respectively, compared with the general population. The incidence of carcinomas remained fairly constant over time, but rates of non-Hodgkin lymphoma decreased from 19802007. The incidence of both esophageal and stomach carcinomas increased with age, and the risk of these cancers among people with AIDS did not decline across calendar years even with the introduction of highly active antiretroviral therapy in 1996.
The researchers provide possible explanations for these results, including an increased prevalence of H. pylori infection in people with AIDS.
10.2012; Vol. 143; No. 4: P. 943-950.e2; E. Christina Persson; Meredith S. Shiels; Sanford M. Dawsey; Kishor Bhatia; Lesley A. Anderson; Eric A. Engels
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