March 26, 2012
Results from a small study of 100 co-infected people treated with Victrelis + pegylated interferon + ribavirin showed that 61% had undetectable viral loads at 12 weeks after stopping their hepatitis C treatment.
All study participants were given pegylated interferon + ribavirin for the first 4 weeks of treatment. About 2/3 had Victrelis added to their regimen for the next 44 weeks while the other third continued on pegylated interferon + ribavirin alone. Nearly all participants were on a boosted protease inhibitor HIV regimen.
The average age of the participants was 44, and 31% were women. Most people had high HCV viral loads, while 5% had cirrhosis. Nearly 65% had HCV genotype 1a while the others had 1b. CD4 counts averaged 580 and all had undetectable HIV viral load.
The following chart describes 12-week post-treatment undetectable HCV viral loads (B/PR = Victrelis + pegylated interferon + ribavirin):
|12 wks post||60.7%||26.5%|
The following details should be noted about this study:
A larger study will start enrolling by the end of the year.
No comments have been made.
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