CROI 2012: HIV/HCV Coinfected People See Improved HCV Cure Rates With Victrelis
March 26, 2012
Results from a small study of 100 co-infected people treated with Victrelis + pegylated interferon + ribavirin showed that 61% had undetectable viral loads at 12 weeks after stopping their hepatitis C treatment.
All study participants were given pegylated interferon + ribavirin for the first 4 weeks of treatment. About 2/3 had Victrelis added to their regimen for the next 44 weeks while the other third continued on pegylated interferon + ribavirin alone. Nearly all participants were on a boosted protease inhibitor HIV regimen.
The average age of the participants was 44, and 31% were women. Most people had high HCV viral loads, while 5% had cirrhosis. Nearly 65% had HCV genotype 1a while the others had 1b. CD4 counts averaged 580 and all had undetectable HIV viral load.
The following chart describes 12-week post-treatment undetectable HCV viral loads (B/PR = Victrelis + pegylated interferon + ribavirin):
A larger study will start enrolling by the end of the year.
This article was provided by Project Inform. Visit Project Inform's website to find out more about their activities, publications and services.
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