Mascolini: Your research shows that MSM adopt serosorting if they learn they're positive7 and that behavioral intervention can cut HIV transmission from positive people by promoting serosorting in MSM.9 But other work shows that serosorting has a modest protective effect when compared with condom use.10 Do you think clinicians should encourage serosorting in HIV-positive MSM?
Morin: You have to look at the relative contribution of serosorting. It's not your first-line strategy for prevention. But among people who are unlikely to use condoms, serosorting can be better than nothing. The primary risk in serosorting is among negative men as opposed to positive men. In fact, many MSM who start serosorting with positive partners after seroconverting were serosorting with negative partners and ended up getting infected.
If you're talking about clinicians working with positive patients and trying to reduce the risk of onward transmission to new partners, discussing serosorting is one task. And if positive MSM are serosorting for positive partners, there are other risks that need to be discussed, including STIs and the challenge to the immune system posed by additional infections.
Mascolini: You've found that clinics with written procedures on positive prevention do a better job delivering positive prevention counseling.3 What other practical steps can medical practices and providers take to promote better prevention services?
Morin: How do clinics get to the point of having written procedures? It usually takes some kind of leadership at a practice level to adopt written procedures as an important thing to do. And that leadership ultimately results in training and procedures, which then get implemented in a clinical setting. If you have that leadership, if you have those written procedures, then prevention interventions are likely to occur. If you don't have the leadership and don't have the written procedures, it's far less likely to occur. The AIDS Education and Training Centers can be a good resource for providers interested in this issue [http://www.aids-ed.org/. Go to "Topic Index" at the bottom of the home page, then click on "Prevention with Positives."]
Mascolini: Will results of HPTN 05211 change the way US HIV physicians and patients think about antiretroviral therapy?
Morin: They should. We've not studied whether it's led to a change in practice. However, you would expect that it would at a minimum start a conversation for clinicians working with serodiscordant couples, because treating the infected partner early can clearly have a beneficial effect in not infecting that negative partner. And I think that message is out there in the clinical community.
HPTN 052 showed that earlier antiretroviral treatment and viral suppression not only prevent onward transmission, but also promote better health outcomes in the infected individual.12 For discordant couples, suppressive antiretroviral therapy taken by the infected partner has a benefit for both partners. Is positive-prevention research making a difference?
Mascolini: HIV incidence remains flat in the US,13 suggesting that HIV-positive people continue to transmit their virus at about the same rate. After all the time and effort you've spent studying positive prevention, do you see any signs that providers or patients are doing better in cutting HIV transmission risk?
Morin: It's hard to say. Let me put it this way: The last 2 years have seen a significant shift in the CDC's approach to HIV prevention -- and the approach in the United States -- with a clear focus on prevention through the National HIV/AIDS Strategy.14 The new strategy also emphasizes treatment outcomes and reducing disparities between different populations. All of that, along with coordination efforts, have put a greater emphasis on the importance of viral suppression as a clinical outcome.
That is being communicated in clinical practices and will increase, one, the frequency of testing among those at risk and, two, the proportion of that population with HIV that is virally suppressed. And as you increase that proportion, or lower community viral load, you should see a decrease in the number of new infections.15,16 This approach is a different way of thinking for this country -- a shift from exclusive condom promotion.
We have yet to see what the impact will be on the CDC projections of new infections. It will take a while for this new approach to take hold and have a significant impact on transmission rates.
Mascolini: What other findings from your work or other work on positive prevention would you like to stress for clinicians caring for HIV-positive patients?
Morin: It's been clear for a long time that, in terms of cost-effectiveness, the more you intervene with HIV-positive people and give them a significant role in HIV prevention leadership, the better off you're going to be. Just focusing on at-risk HIV negatives is not as cost-effective as working with people who are aware of their infection and who are willing to partner with the provider in trying to prevent onward transmission.
|What Are Effective HIV Prevention Models for Use in Health Care Settings?|
Excerpted from: How can HIV prevention be integrated into health care settings? Center for AIDS Prevention (CAPS) Fact Sheet 68. July 2010. Prepared by Carol Dawson-Rose, Janet Myers and Karen McCready.
Positive STEPs is a training intervention to help HIV care providers deliver prevention counseling to their patients. The model was effective in improving provider attitudes, comfort, self-efficacy and frequency of delivering prevention counseling.1
Partnership for Health is an EBI (CDC's Effective Behavioral Intervention) for providers in HIV clinics. Medical providers are trained to deliver brief risk-reduction counseling to their patients. All clinic staff are trained to integrate prevention messages into the clinic setting, and counseling is supplemented with written information for all patients. The intervention was effective in reducing unprotected intercourse by 38% among patients who had two or more sex partners.2
Positive Choice is an interactive "Video Doctor." Patients at HIV clinics complete an in-depth computerized risk assessment and receive tailored risk-reduction counseling from a "Video Doctor" via laptop computer and a printed educational worksheet. Providers receive a Cueing Sheet on reported risks for discussion during the clinical encounter.3
Provider-Delivered Counseling. In a large federal demonstration project, brief counseling messages delivered by primary care providers in clinic settings were most effective in reducing risk among HIV-infected patients, although there were also benefits in programs delivered by prevention specialists and HIV-infected peers.4
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