In this analysis of data from the historic Women's Interagency HIV Study, HAART decreased immune activation, exhaustion, senescence, and apoptosis in CD8+ T cells (cohort mean age: 41.2 years). However, these levels did not become normalized even after a year of HAART. Therapies that reverse immune system aging used in combination with HAART may be warranted, the research suggests.
For more information, read CROI poster 331, "Impact of HAART Initiation on Immune Regulation in Aging HIV+ Women: Women's Interagency HIV Study," presented by Seema Desai.
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