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TheBody.com/TheBodyPRO.com covers The 19th Conference on Retroviruses and Opportunistic Infections (CROI 2012)

HIV Linked to Shorter Telomeres, a Sign of Aging

A Poster Spotlight From CROI 2012

March 7, 2012

Nelson Vergel, B.S.Ch.E., M.B.A.

Nelson Vergel, B.S.Ch.E., M.B.A.

A telomere is a repeating sequence of nucleotides that protects the end of a chromosome. Telomeres shorten with aging. HIV-induced inflammation and the use of nucleoside analog drugs may accelerate telomere shortening.

A team from the University of British Columbia compared telomere length in leukocytes between 220 HIV-infected people (80% of them women, mean age 39) and 166 HIV-uninfected controls (71% of them women, mean age 39).

As expected, older age was predictive of shorter telomere length. HIV had a moderate negative effect on telomere length, but the strongest association was found with cigarette smoking, a source of oxidative stress that can accelerate cellular aging. Those who were both HIV infected and smoked had the worst telomere length, a sign of accelerated cellular aging.

For more information, read CROI poster 307, "HIV Infection Is Marginally Associated with Shorter Leukocyte Telomere Length," presented by DeAnna Zanet.


Copyright © 2012 Remedy Health Media, LLC. All rights reserved.




This article was provided by TheBodyPRO.com. It is a part of the publication The 19th Conference on Retroviruses and Opportunistic Infections.
 


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Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

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