March 1, 2012
Facts About Statins and Protease Inhibitors
The labels for both the HIV protease inhibitors and the affected statins have been updated to contain consistent information about the drug-drug interactions. These labels also have been updated to include dosing recommendations for those statins that may safely be co-administered with HIV or HCV protease inhibitors (see Statin Dose Limitations below).
Healthcare professionals should refer to the current drug labels for protease inhibitors and statins for the latest recommendations on prescribing these drugs.
Patients should contact their healthcare professional if they have any questions or concerns about taking protease inhibitors and statins.
The results from a drug-drug interaction study with atorvastatin and lopinavir/ritonavir that were previously in the atorvastatin label have not yet been validated. Therefore, these results have been removed from the label and the dose cap of atorvastatin 20 mg when co-administered with lopinavir/ritonavir has also been removed. Pending validation of the study, healthcare professionals should use caution when co-administering atorvastatin with lopinavir/ritonavir and use the lowest necessary dose of atorvastatin.
Lovastatin and simvastatin are sensitive in vivo cytochrome P450 3A4 (CYP3A4) substrates. Therefore, strong CYP3A4 inhibitors are predicted to significantly increase lovastatin and simvastatin exposures. A literature review indicates that itraconazole, a strong CYP3A4 inhibitor, increases lovastatin exposure up to 20-fold, and the drug interaction appears to result in rhabdomyolysis.1 Itraconazole increases simvastatin exposure up to 13-fold. Hence, other CYP3A4 inhibitors, including ketoconazole, posaconazole, erythromycin, clarithromycin, telithromycin, nefazodone, human immunodeficiency virus (HIV) protease inhibitors, and the hepatitis C virus (HCV) protease inhibitors boceprevir and telaprevir, are also expected to significantly increase lovastatin and simvastatin exposures. Therefore, concomitant administration of lovastatin and simvastatin with HIV protease inhibitors or HCV protease inhibitors (boceprevir and telaprevir) is contraindicated.
The HIV protease inhibitor combinations lopinavir/ritonavir and atazanavir/ritonavir increase rosuvastatin exposure up to 3-fold. For these combinations, the dose of rosuvastatin should be limited to 10 mg.
|Statin Dose Limitations|
|Statin||Interacting Protease Inhibitor(s)||Prescribing Recommendation|
|Use with caution and use with the lowest atorvastatin dose necessary|
|Do not exceed 20 mg atorvastatin daily|
|Do not exceed 40 mg atorvastatin daily|
|Fluvastatin||No data available|
||No dose limitations|
||No dose limitations|
||Limit rosuvastatin dose to 10 mg once daily|
HIV = human immunodeficiency virus
No comments have been made.
The content on this page is free of advertiser influence and was produced by our editorial team. See our content and advertising policies.
|Incidence of All Cancers but Lung Cancer Drops After HIV Group Stops Smoking|
|New HIV Infections Drop 18% in 6 Years|
|The Company You Keep: Do Social Networks Influence HIV Status?|
|HIV-Associated Neurocognitive Disorders and the Gut Microbiome|
|Implementation of a Rapid HIV Diagnostic and Referral Strategy|
|Antibody Therapies Effective at Preventing HIV From Invading CD4 Cells|