January 20, 2012
A combination of antiviral drugs boosted treatment results for hepatitis C virus (HCV) patients who had been unresponsive to previous therapy, according to a preliminary study.
The open-label, Phase 2a trial involved 21 patients with chronic HCV who were randomly assigned to receive two antivirals, the NS5A replication complex inhibitor daclatasvir (60 mg once daily) and the NS3 protease inhibitor asunaprevir (600 mg twice daily), either alone or in combination with peginterferon alfa-2a and ribavirin.
Among those receiving only the two antivirals, 36 percent had a sustained virologic response (SVR) over 24 weeks of treatment. All but one of the patients on the four-drug combination achieved SVR after 24 weeks. Patients with HCV genotype 1b had a particularly strong response to the antivirals. Studies are ongoing to further evaluate combinations of antivirals against HCV.
"We are on the threshold of a treatment revolution that will greatly improve the effectiveness of [HCV] therapy by dramatically increasing the number of persons treated," Dr. Raymond T. Chung, director of hepatology at Massachusetts General Hospital, wrote in an accompanying editorial.
The report, "Preliminary Study of Two Antiviral Agents for Hepatitis C Genotype 1," and the editorial, "A Watershed Moment in the Treatment of Hepatitis C," were published in the New England Journal of Medicine (2012;366:216-224 and 273-275, respectively).
Los Angeles Times
01.18.2012; Shari Roan
No comments have been made.
The content on this page is free of advertiser influence and was produced by our editorial team. See our content and advertising policies.
|CDC Corrects Misleading HIV Conception Guidance, Responding to Community Pressure|
|This Week in HIV Research: Injectable PrEP Shows Promise in New Study|
|New York Study Finds Almost Half of HIV-Positive Gay Men Co-Infected With Hepatitis C Have Detectable Levels of Hepatitis C Virus in Their Rectal Fluid|
|This Week in HIV Research: New Discovery in How HIV Hijacks a Cell|
|This Week in HIV Research: A New Glimpse Into HAND|
|Mosaic HIV Vaccine Candidate Shows Promise in Early-Stage Trial|