September 20, 2011
A 24-week course of treatment for chronic hepatitis C virus (HCV) infection that added telaprevir to peginterferon and ribavirin was just as effective as a 48-week regimen for many patients in the current study.
This multicenter research enrolled 540 treatment-naïve patients with chronic infection with HCV genotype 1. All received telaprevir (Incivek), peginterferon alfa-2a and ribavirin for 12 weeks, after which telaprevir was suspended.
Patients who had an extended rapid virologic response (ERVR) (undetectable HCV RNA levels at weeks 4 and 12) were randomly assigned, after week 20, to receive dual therapy for four more weeks (24-week group) or for 28 more weeks (48-week group). Patients without ERVR were assigned to the 48-week group.
"In this study, among patients with chronic HCV infection who had not received treatment previously, a regimen of peginterferon-ribavirin for 24 weeks, with telaprevir for the first 12 weeks, was noninferior to the same regimen for 48 weeks in patients with undetectable HCV RNA at weeks 4 and 12, with [ERVR] achieved in nearly two-thirds of patients," the authors concluded.
New England Journal of Medicine
09.15.2011; Vol. 365: P. 1014-1024; Kenneth E. Sherman, M.D., Ph.D., and others
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