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After earning his undergraduate and medical degrees from the University of Washington-Seattle, Dr. O'Brien completed his internal medicine residency at the University of California-San Francisco. He is an accredited HIV specialist by the American Academy of HIV Medicine (AAHIVM), serves on the board of directors for AAHIVM's California chapter and is co-chair of the AAHIVM public policy committee. A published physician and periodic lecturer, Dr. O'Brien also acts as a consultant to the Alameda County Office of AIDS Administration, which oversees HIV prevention and care efforts for the East Bay portion of the San Francisco Bay Area, including Berkeley, Fremont and Oakland.