Thanks for your post.
Sorry to hear about your mother's needle stick. The choice of medications for post-exposure prophylaxis is subject to many regional polices and procedures. AZT+3TC (Combivir) is frequently used. Here in Colorado, US, indinavir (Crixivan) is generally not used for PEP, though other protease inhibitors (eg Kaletra) are.
In your mother's case, it is relevant to know that indinavir may make your mother's sugar control more difficult for the 4 weeks she takes PEP. Clearly her tolerance of the medications seems suboptimal.
We generally encourage our PEP patients to complete the 4 weeks of treatment; if it looks like the Crixivan is the culprit, one could consider stopping Crix and continuing the Combivir through the end.
Best of luck to you (and her).
BY
