zidovudine induced anemia?
Posted: Jul 16, 2007
QUESTION:
heelo sir, i have a child 9 yr old put on AZT+3TC+NVP sincee 14 months with baseline Hb of 13.4gm, WBC 5000/cumm. on six months of treatment the CBC was within normal limits. now she has developed pancytopenia with Hb 2.4 gm%, WBC1900/cumm, platelets 50000/cumm, MCV 109 fl. could this be due to AZT(14 mon on treatment)?
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RESPONSE FROM:
Thank you for your post.
AZT (zidovudine) can certainly cause bone marrow suppression-- most commonly anemia. I'd be sure to look for other potential causes, such as infection, but if no other secondary causes are identified, switching the child off AZT to an alternative NRTI could be considered.
Hope this helps. BY
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