I hear your frustration and yeah we know - lives are at stake. So you need to get in touch with your physician, and an HIV expert if your own physician is not one - to plan the next moves. Since there are some ideas that sometimes help... and can make it worth the effort.
There are other antivirals in active development specifically for people who have HIV that is resistant to current treatments. Fortunately the pharmaceutical industry continues to focus efforts on finding the next generation of options that will work despite resistant strains of HIV.
For example - there is another drug that is related to T20 called T1249 and it appears to maintain activity for at least some people after T20 resistance. Studies are in planning stages and depending on where you are, you might consider participation in one of these.
But that is likely to be months away. And right now the one drug that is undergoing large scale (phase 3) testing is called tipranavir - it is a protease inhibitor that remains active even after there is other PI resistance - up to a point. So if you are near a site that is doing tipranavir research, you might be eligible for a study of this drug. It is likely over a year away from being a prescription drug - so studies of this or other treatments are likely the only choices available to have a big impact on your HIV infection. And since I don't know where you are I don't know what research options you might have - but research is happening on new compounds in many cities across the world.
Constructing a regimen that works after resistance is among the most challenging aspect of HIV treatment - be sure that your clinician and you are working together to review your current meds, to be sure that you are doing what can be done to at least partially control HIV with the available medications. We must also work to improve your side effects - and importantly your outlook. Since the depression and hopeless feelings you mention are central to what we as clinicians must address in taking care of you and your life.
Good luck - hope this helps.
