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Hep C

Posted: Feb 19, 2003

QUESTION:

There are reports stating that HCV is curable in half of HIV-infected patients. How is "curable" defined. It is widely understood that a virus can not be cured but just treated and the immune system surpresses a virus and keeps it in check. Is the term "cured" correct or is it in regression and at what levels?


  

RESPONSE FROM:   

    Curable is one of those dangerous terms--- nevertheless, in a large proportion of persons with HIV who are coinfected with HCV, combination therapy with interferon and ribavirin can produce durable HCV virologic suppresion (known as "sustained virologic response") months after treatment is discontinued.

    This is a key point, since virologic suppression can lead to reversal of liver injury and prevention of cirrhosis or other compliations. Persons with HCV genotypes 2 or 3 respond best to treatment and are most likely to have SVRs.




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