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HAART and pulmonary tuberculosis

Posted: Sep 5, 2006

QUESTION:

A patient in HAART cd4 120 with NVP 400 mg, AZT 600 mg 3TC 300 mg and pulmonary tuberculosis goes to begin treatment with streptomycin rifampicin isoniazid ethambutol and pyrazinamide ¿what changes I should make in HAART?


  

RESPONSE FROM:   

    Generally, co-administration of nevirapine (NVP) and rifampicin is not recommended as the level of NVP drops considerably with rifampicin. If possible, a switch to efavirenz at 800 mg before bed should be considered (no change to rifampicin dose). If there is no choice but to use NVP, you would use standard doses of both NVP and rifampicin.

    DW




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