Thanks for your post.
Higher that usual dose of protease inhibitors (like lopinavir/ritonavir-Kaletra) can overcome some degree of drug resistance. It appears to me that your doctor's older does of Kaletra (3 tablets twice daily) may have been aimed at doing just this.
The lower dose of Kaletra would have resulted in lower levels of lopinavir, possibly low enough to permit viral escape. A resistance test would help, particularly one that included a phenotype.
There seems little harm to me in going back to the higher Kaletra dose; though if there is any level of drug resistance to protease inhibitors in your virus, I'd be inclined to drop the Kaletra for Norvir-boosted darunavir (Prezista). A recently concluded clinical study showed Prezista to be far better (and less toxic) than the old guard Kaletra.
BY
