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PIs/TB

Posted: Jan 14, 2007

QUESTION:

my patient have aids + TB his resistance test :NRTI & NNRTIs (R);3TC&PIs (s) CD4% :6%; CD4: 126;Viral load:86000/ml he is on Rifampicin,INH Could we use PIs ? dose?


  

RESPONSE FROM:   

    Thanks for your post.

    There are a number of very serious drug-drug interactions between PIs and rifampin-- I wouldn't recommend their combined use.

    By contrast, if you have access to rifabutin, PIs can be used without as significant a risk of drug interactions.

    Clearly your patient needs to be on effective HAART, without rifabutin, your options would appear to be seriously limited until your patient can safely discontinue rifampin.

    Hope this helps, BY




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